Efavirenz Dissolution Enhancement I: Co-Micronization
نویسندگان
چکیده
منابع مشابه
Efavirenz Dissolution Enhancement I: Co-Micronization
AIDS constitutes one of the most serious infectious diseases, representing a major public health priority. Efavirenz (EFV), one of the most widely used drugs for this pathology, belongs to the Class II of the Biopharmaceutics Classification System for drugs with very poor water solubility. To improve EFV's dissolution profile, changes can be made to the physical properties of the drug that do n...
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Efavirenz is an HIV-1 specific, non-nucleoside reverse transcriptase inhibitor (NNRTI).It is an antiretroviral agent indicated for the treatment of human immunodeficiency virus type 1 (HIV-1) infection, which is not soluble in water and lower absorption in gastric fluid. In order to improve the solubility and oral absorption of the drug in gastric fluid and to enhance its dissolution rate, soli...
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ژورنال
عنوان ژورنال: Pharmaceutics
سال: 2012
ISSN: 1999-4923
DOI: 10.3390/pharmaceutics5010001